Pauline Clément trained at the Cours Florent, the Conservatoire of the 8th arrondissement in Paris and the School of the Studio d’Asnières. In 2006, she played in Les Quatre filles du docteur Chekhov, a play written, directed and co-interpreted by Eugénie de Bohent. She then interpreted La Ballade de Jack et Jane, together with its author and director Frédéric Losseroy.
Louise Lévêque cast her in several pieces, such as Les salamandres dansent after texts written by Marina Tsvetaeva; Pantagruel, le banquet spectacle after Rabelais; and Goethe’s Urfaust. In 2007, Sophie Engel selected her to play in Botho Strauss’s Visages connus, sentiments mêlés.
In 2011, Pauline Clément trained with Gérard Desarthe, Laurent Natrella, Caroline Marcadé and Yvo Mentens at the Conservatoire national supérieur d’art dramatique. In 2013, she played in Dostoyevsky’s The Dream of a Ridiculous Man directed by Élise Lhomeau.
In 2014, she played in Berliner Mauer: vestiges, a collective creation directed by Jade Herbulot and Julie Bertin. The same year, she appeared on stage by herself in Comme la lune, a piece written and directed by Bertrand Usclat.

Pauline Clément joined the Comédie-Française as pensionnaire on the 8th of December 2015. She made her debut in Karl Kraus’ The Last Days of Mankind directed by David Lescot. In 2016, Giorgio Barberio Corsetti cast her as Nonancourt’s daughter Hélène, in Eugene Labiche’s An Italian Straw Hat (Un chapeau de paille d’Italie), while Anne Kessler entrusted her with the Prostitute’s part in Arthur Schnitzler’s La Ronde. The following year, under the direction of Christiane Jatahy she interpreted Jacqueline in The Rules of the Game (La Règle du jeu) after Jean Renoir’s screenplay, followed by the role of Victoire, Pinglet’s chamber maid, in George Feydeau’s The Free Exchange Hotel (L’Hôtel du Libre-Échange) by Isabelle Nanty. Denis Podalydès cast her as Hyacinte in Les Fourberies de Scapin by Molière.

Outside the Comédie-Française, Pauline Clément is part of a collective of comedians Yes Vous Aime, which broadcasts on the Internet.
She has appeared in two short films by Guillaume Cremonese and Bertrand Usclat, Amer and Partie fine. In 2016, she was part of the cast of the movie C’est la Vie! (Le Sens de la fête) by Olivier Nakache and Éric Tolédano and, in 2017, she was in Lola et ses frères, a feature film by Jean-Paul Rouve.

During the 2018/2019 season, Pauline Clément plays in Les Oubliés (Alger-Paris) written and directed by Julie Berton and Jade Herbulot – Le Birgit Ensemble and in the rerun of Feydeau’s The Free Exchange Hotel (L’Hôtel du Libre-Échange) by Isabelle Nanty.